Why This Study Matters
PVP-I is known to be safe on the skin and in the mouth, but using it inside the nose introduces potential questions about how much iodine gets absorbed into the bloodstream. This matters for people with thyroid concerns, pregnant individuals, and anyone using the spray daily.
That’s exactly what this Phase I human study focused on—quantifying iodine absorption from 0.5% Nasodine® nasal spray, a commercially available formulation.
What the Study Found
- Minimal iodine uptake: Blood iodine levels remained within normal limits, even after multiple applications.
- No thyroid dysfunction detected: Thyroid hormones remained stable throughout the study period.
- Safe profile confirmed: No adverse events or side effects were reported, even in repeated use.
The authors concluded that using 0.5% PVP-I nasal spray does not result in clinically significant iodine absorption, reinforcing its safety for repeated use.
Who This Applies To
This study is especially important for:
- Healthcare workers or other high-risk individuals using PVP-I multiple times a day
- People with thyroid sensitivity concerned about iodine exposure
- Long-term users who plan to use the spray during cold and flu seasons or future viral outbreaks
It also provides further backing for public health recommendations that include nasal disinfection protocols—without risking thyroid health or systemic iodine overload.
Final Thoughts
It’s one thing for a nasal spray to be effective; it’s another for it to be systemically safe. This Phase I study checks that box for 0.5% povidone-iodine, showing that you can use it regularly without affecting your iodine levels or thyroid function.
As more people look for accessible, everyday tools to reduce infection risk, this kind of data is critical—and very reassuring.
Read the full study here: Phase 1 Study of the Iodine Absorption, Safety, and Tolerability of a 0.5% Povidone Iodine Nasal Spray
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