Povidone-iodine (PVP-I) is a powerful antiseptic with proven virucidal activity. In a 0.6% concentration, PVP-I has been formulated into an oro-nasal spray that coats the nasal and oral mucosa—key entry points for viruses like SARS-CoV-2. By doing so, it:
- Blocks viral binding to ACE2 receptors
- Neutralizes the virus on contact
- Reduces viral transmission from both symptomatic and asymptomatic individuals
Why a Spray Instead of Drops?
Compared to nasal drops, nasal sprays offer:
- Deeper diffusion into the nasopharynx
- Longer retention time
- Ease of use in upright positions
This makes sprays a more effective and practical delivery system, especially for healthcare workers on the go.
Clinical Insight: The Author’s Experience
ENT surgeon Dr. Mostafa Kamal Arefin and his team have used the 0.6% PVP-I oro-nasal spray routinely:
- During over 7000 patient consultations
- For 501 endoscopies and 203 surgeries, including high-risk tracheostomies
- Even after direct exposure to COVID-19 patients, no infections were reported among the team using the spray
His experience supports the idea that this spray adds a layer of real-world protection, especially during high-exposure procedures.
Benefits of 0.6% PVP-I Spray
Medical Benefits
- Broad-spectrum virucidal activity (including SARS-CoV-2)
- Pre- and post-exposure protection
- Reduces nasal congestion, sore throat, and viral load
- No known resistance development
Safety Profile
- No significant side effects at 0.6% concentration
- Minimal risk of mucosal irritation or thyroid disruption
- Safe for long-term use
Benefits of the Spray Format
- Single container for both nasal and oral application
- Compact, portable, and easy to use
- No need for sinks or gargling facilities
- Refillable and cost-effective
- Minimal iodine exposure with maximum efficiency
Who Should Use It?
For Healthcare Workers:
- Before patient interaction (any patient, not just COVID-positive)
- Before surgeries, especially ENT or aerosol-generating procedures
- After exposure to known or suspected COVID-19 cases
For the Public:
- Before and after attending gatherings, work, or travel
- Multiple times daily, including after meals or returning home
For COVID-19 Patients:
- Helps reduce viral shedding
- May lower household and caregiver transmission risk
How to Use
- 2–3 sprays per nostril
- 1–3 sprays in the throat
- Repeat every 3–4 hours, with a weekly break after 1–2 weeks of use
Final Thoughts
Masks, PPE, and vaccines are essential—but not foolproof.
PVP-I oro-nasal spray may offer an additional, low-cost, science-backed defense. With no significant side effects, easy accessibility, and broad usage potential, it’s a tool worth considering for healthcare workers, patients, and the general public alike.
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