PVP-I Use Cases

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July 16, 2025

Understanding the Use of Povidone-Iodine Throat Spray in Infection Prevention

In the fight against sore throats and seasonal viruses, throat disinfectant sprays offer a convenient layer of defense. Among them, povidone-iodine sprays stand out for their strong antiseptic action and ease of use.

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Povidone-iodine (PVP-I) has long been recognized for its potent disinfectant properties. Used in hospitals and homes alike, this broad-spectrum antiseptic is now available in convenient over-the-counter (OTC) formats, such as throat sprays. One such product is “Nodonu-ru Spray B,” a Japanese throat disinfectant spray developed by Kobayashi Pharmaceutical Co., Ltd. This blog explores how the spray works, its safety guidelines, and precautions for effective use.

What Is Povidone-Iodine Throat Spray?

Povidone-iodine throat sprays are designed to disinfect the throat area, helping to reduce bacteria and viruses at the site of entry. The active ingredient, iodine (0.5 g per 100 mL), targets the mucous membranes of the throat, potentially lowering the risk of infection and offering symptom relief during colds or sore throats.

Key Ingredients

In addition to iodine, this product includes:

  • Potassium iodide
  • Glycerin
  • Propylene glycol
  • D-sorbitol
  • Ethanol
  • L-menthol
  • Fragrance

These inactive ingredients support the spray’s stability, moisture retention, and flavor, while ethanol and menthol provide a soothing, cooling effect.

Usage Directions

To ensure safe and effective use:

  • Spray directly at the affected area of the throat, while gently exhaling (never inhale during spraying to avoid respiratory complications).
  • Use several times a day, but do not spray large amounts or overuse it long-term.
  • Children should only use the spray under adult supervision.
  • The spray is for throat use only—do not apply it to the eyes or ingest large quantities.

Who Should Not Use This Product?

The following individuals should not use povidone-iodine throat sprays:

  • Those allergic to iodine or any of the product’s ingredients
  • Individuals with thyroid disease
  • Infants under 2 years old
  • Pregnant or breastfeeding individuals

Consult a Healthcare Professional If:

Before using the product, consult a doctor, dentist, or pharmacist if you:

  • Are under treatment for a medical or dental condition
  • Have a history of medication allergies
  • Have severe mouth erosion or ulceration

Stop using immediately and seek medical advice if you experience:

  • Skin issues: Rash, itching, redness
  • Mouth issues: Burning, irritation, stinging
  • Digestive symptoms: Nausea
  • Other symptoms: General discomfort or allergic reactions

In rare cases, signs of anaphylactic shock may occur, including:

  • Itchy skin, hives, hoarseness, sneezing
  • Throat swelling or irritation
  • Difficulty breathing
  • Palpitations
  • Loss of consciousness

If any of these occur, seek emergency medical help immediately.

Storage and Handling

To keep the spray safe and effective:

  • Store upright in a cool, dry place, away from sunlight.
  • Keep out of reach of children.
  • Do not transfer to another container.
  • After use, secure the cap and store with the nozzle in place.
  • If spilled on clothing, rinse immediately with water.

Final Thoughts

While povidone-iodine throat sprays like Nodonu-ru Spray B can be effective tools for local disinfection, they should be used responsibly. Always follow the label instructions and consult with healthcare professionals if uncertain about usage—especially if you have pre-existing health conditions.

With proper use, PVP-iodine sprays may offer a helpful layer of defense in daily hygiene routines, especially during cold and flu season.

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